WORLD NEWS
Human marrow-on-a-chip exposed how antibody cells move and settle
Human B cells were matured into antibody-secreting plasma cells and moved into a chip with two marrow-like niches.
The platform can test questions and candidates but cannot establish clinical efficacy or long-term safety.
System
An inactivated-flu organoid stage was linked to microfluidic perivascular and endosteal-like niches.
Observation
Hair-width channels enabled high-resolution imaging of movement, stopping and survival signals.
Importance
Long-lived plasma cells sustain antibodies; dysregulation can contribute to allergy, autoimmunity and blood cancer.
Limits
Donor cells, artificial gels and growth factors simplify a body with circulation, nerves, hormones and many cell types.
Next
Different donors and diseases must reproduce results, followed by comparison with animals and patient samples.
Primary source and independent checks
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