{"id":930,"date":"2026-07-29T05:35:00","date_gmt":"2026-07-28T20:35:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-07-29-als-19-protein-onset-panel-vi\/"},"modified":"2026-07-29T05:35:00","modified_gmt":"2026-07-28T20:35:00","slug":"2026-07-29-als-19-protein-onset-panel-vi","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-07-29-als-19-protein-onset-panel-vi\/","title":{"rendered":"19 protein m\u00e1u \u01b0\u1edbc t\u00ednh th\u1eddi \u0111i\u1ec3m xu\u1ea5t hi\u1ec7n ALS v\u1edbi sai s\u1ed1 trung b\u00ecnh 1,6 n\u0103m"},"content":{"rendered":"

2026-07-29 05:35 KST<\/strong><\/p>\n

\u1ede ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 di truy\u1ec1n ALS cao, b\u1ea3ng 19 protein m\u00e1u \u01b0\u1edbc t\u00ednh th\u1eddi \u0111i\u1ec3m c\u00f3 tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng v\u1edbi sai s\u1ed1 tuy\u1ec7t \u0111\u1ed1i trung b\u00ecnh 1,62 n\u0103m.<\/p>\n

\u0110\u00e2y kh\u00f4ng ph\u1ea3i x\u00e9t nghi\u1ec7m s\u1edbm cho m\u1ecdi ng\u01b0\u1eddi m\u00e0 l\u00e0 k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u nh\u1eb1m ch\u1ecdn \u0111\u00fang ng\u01b0\u1eddi mang bi\u1ebfn th\u1ec3 v\u00e0 th\u1eddi \u0111i\u1ec3m cho th\u1eed nghi\u1ec7m ph\u00f2ng ng\u1eeba.<\/p>\n

Nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n g\u00ec<\/h2>\n

T\u1eeb \u0111o\u00e0n h\u1ec7 Pre-fALS \u0111\u01b0\u1ee3c theo d\u00f5i kho\u1ea3ng 18 n\u0103m tr\u01b0\u1edbc v\u00e0 sau tri\u1ec7u ch\u1ee9ng, nh\u00f3m nghi\u00ean c\u1ee9u t\u00ecm th\u1ea5y 92 protein thay \u0111\u1ed5i tr\u01b0\u1edbc khi bi\u1ec3u hi\u1ec7n b\u1ec7nh v\u00e0 r\u00fat xu\u1ed1ng b\u1ea3ng l\u00f5i 19 protein.<\/p>\n

B\u1ea3ng n\u00e0y ph\u00e2n bi\u1ec7t kh\u1ea3 n\u0103ng xu\u1ea5t hi\u1ec7n ALS l\u00e2m s\u00e0ng trong 0,5, 1, 2, 3 v\u00e0 5 n\u0103m. AUC ki\u1ec3m \u0111\u1ecbnh ch\u00e9o l\u00e0 0,80\u20130,89.<\/p>\n

Quy m\u00f4 v\u00e0 \u00fd ngh\u0129a c\u1ee7a 1,6 n\u0103m<\/h2>\n

Ph\u00e2n t\u00edch d\u00f9ng 516 m\u1eabu huy\u1ebft t\u01b0\u01a1ng n\u1ed1i ti\u1ebfp t\u1eeb 33 ng\u01b0\u1eddi chuy\u1ec3n sang c\u00f3 tri\u1ec7u ch\u1ee9ng, 35 b\u1ec7nh nh\u00e2n ALS, 10 ng\u01b0\u1eddi mang bi\u1ebfn th\u1ec3 ch\u01b0a c\u00f3 tri\u1ec7u ch\u1ee9ng v\u00e0 59 \u0111\u1ed1i ch\u1ee9ng.<\/p>\n

Sai s\u1ed1 1,62 n\u0103m kh\u00f4ng b\u1ea3o \u0111\u1ea3m ng\u00e0y ph\u00e1t b\u1ec7nh c\u1ee7a t\u1eebng c\u00e1 nh\u00e2n. \u0110\u00e2y l\u00e0 trung b\u00ecnh ch\u00eanh l\u1ec7ch tuy\u1ec7t \u0111\u1ed1i gi\u1eefa th\u1eddi \u0111i\u1ec3m d\u1ef1 \u0111o\u00e1n v\u00e0 quan s\u00e1t trong \u0111o\u00e0n h\u1ec7 kh\u00e1m ph\u00e1.<\/p>\n

\"H\u00ecnh
H\u00ecnh minh h\u1ecda do ONEPRESS t\u1ea1o: kh\u00f4ng m\u00f4 t\u1ea3 ph\u00f2ng th\u00ed nghi\u1ec7m, ng\u01b0\u1eddi tham gia, thi\u1ebft b\u1ecb hay c\u1ea5u tr\u00fac th\u1eadt c\u1ee7a 19 protein; h\u00ecnh th\u1ec3 hi\u1ec7n kh\u00e1i ni\u1ec7m proteomics m\u00e1u \u1edf giai \u0111o\u1ea1n nghi\u00ean c\u1ee9u.<\/figcaption><\/figure>\n

V\u00ec sao quan tr\u1ecdng v\u1edbi th\u1eed nghi\u1ec7m ph\u00f2ng ng\u1eeba<\/h2>\n

Tri\u1ec7u ch\u1ee9ng ALS xu\u1ea5t hi\u1ec7n sau khi t\u1ed5n th\u01b0\u01a1ng n\u01a1ron v\u1eadn \u0111\u1ed9ng \u0111\u00e3 b\u1eaft \u0111\u1ea7u. Kh\u00f4ng bi\u1ebft ai s\u1ebd ph\u00e1t b\u1ec7nh v\u00e0 khi n\u00e0o khi\u1ebfn th\u1eed nghi\u1ec7m tr\u01b0\u1edbc tri\u1ec7u ch\u1ee9ng ph\u1ea3i l\u1edbn v\u00e0 k\u00e9o d\u00e0i.<\/p>\n

Nh\u1eadn di\u1ec7n ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec3u hi\u1ec7n s\u1edbm c\u00f3 th\u1ec3 gi\u00fap th\u1eed thu\u1ed1c \u0111\u00fang th\u1eddi \u0111i\u1ec3m h\u01a1n. Nghi\u00ean c\u1ee9u n\u00e0y kh\u00f4ng ch\u1ee9ng minh b\u1ea5t k\u1ef3 \u0111i\u1ec1u tr\u1ecb n\u00e0o ng\u0103n ho\u1eb7c tr\u00ec ho\u00e3n ALS.<\/p>\n

D\u1eef li\u1ec7u ngo\u00e0i c\u00f3 sai s\u1ed1 l\u1edbn h\u01a1n<\/h2>\n

UK Biobank t\u00e1i hi\u1ec7n m\u1ed9t ph\u1ea7n thay \u0111\u1ed5i protein tr\u01b0\u1edbc tri\u1ec7u ch\u1ee9ng v\u00e0 xu h\u01b0\u1edbng b\u1ea3ng nhi\u1ec1u protein t\u1ed1t h\u01a1n ch\u1ec9 d\u00f9ng neurofilament light.<\/p>\n

Nh\u01b0ng d\u1eef li\u1ec7u l\u00e0 c\u1eaft ngang v\u00e0 gi\u1ea3 \u0111\u1ecbnh th\u1eddi \u0111i\u1ec3m bi\u1ec3u hi\u1ec7n tr\u01b0\u1edbc l\u1ea7n nh\u1eadp vi\u1ec7n li\u00ean quan hai n\u0103m. B\u1ea3ng 15 protein c\u00f3 sai s\u1ed1 trung b\u00ecnh 2,75 n\u0103m.<\/p>\n

V\u00ec sao ch\u01b0a ph\u1ea3i x\u00e9t nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n<\/h2>\n

\u0110o\u00e0n h\u1ec7 kh\u00e1m ph\u00e1 nh\u1ecf v\u00e0 t\u1eadp trung v\u00e0o bi\u1ebfn th\u1ec3 ALS gia \u0111\u00ecnh, n\u00ean ch\u01b0a th\u1ec3 \u00e1p d\u1ee5ng th\u1eb3ng cho ALS r\u1ea3i r\u00e1c hay s\u00e0ng l\u1ecdc d\u00e2n s\u1ed1. C\u1ea7n x\u00e9t nghi\u1ec7m chu\u1ea9n h\u00f3a v\u00e0 x\u00e1c nh\u1eadn ti\u1ebfn c\u1ee9u \u0111\u1ed9c l\u1eadp.<\/p>\n

T\u00ednh \u0111\u1ebfn 29\/7\/2026, b\u1ea3ng n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n ho\u1eb7c s\u00e0ng l\u1ecdc. X\u00e9t nghi\u1ec7m di truy\u1ec1n v\u00e0 t\u01b0 v\u1ea5n nguy c\u01a1 c\u1ea7n th\u1ef1c hi\u1ec7n qua chuy\u00ean khoa v\u00e0 t\u01b0 v\u1ea5n di truy\u1ec1n.<\/p>\n

Ngu\u1ed3n s\u01a1 c\u1ea5p ch\u00ednh th\u1ee9c<\/h2>\n

Nature Medicine: nghi\u00ean c\u1ee9u g\u1ed1c theo d\u00f5i d\u1ecdc h\u1ec7 protein huy\u1ebft t\u01b0\u01a1ng<\/a><\/p>\n

NIH: thi\u1ebft k\u1ebf, k\u1ebft qu\u1ea3 v\u00e0 \u00fd ngh\u0129a v\u1edbi th\u1eed nghi\u1ec7m ph\u00f2ng ng\u1eeba<\/a><\/p>\n

\u0110\u1ea1i h\u1ecdc Miami: b\u1ed1i c\u1ea3nh, ph\u1ea1m vi v\u00e0 gi\u1edbi h\u1ea1n l\u00e2m s\u00e0ng<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u1ede ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 di truy\u1ec1n ALS cao, b\u1ea3ng 19 protein m\u00e1u \u01b0\u1edbc t\u00ednh th\u1eddi \u0111i\u1ec3m xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng v\u1edbi sai s\u1ed1 tuy\u1ec7t \u0111\u1ed1i trung b\u00ecnh 1,62 n\u0103m. \u0110\u00e2y ch\u01b0a ph\u1ea3i x\u00e9t nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n l\u00e2m s\u00e0ng.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-930","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}