{"id":888,"date":"2026-07-27T09:50:00","date_gmt":"2026-07-27T00:50:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-07-27-condenzymes-catalysis-vi\/"},"modified":"2026-07-27T09:50:00","modified_gmt":"2026-07-27T00:50:00","slug":"2026-07-27-condenzymes-catalysis-vi","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-07-27-condenzymes-catalysis-vi\/","title":{"rendered":"Gi\u1ecdt l\u1ecfng trong t\u1ebf b\u00e0o tr\u1edf th\u00e0nh ch\u1ea5t x\u00fac t\u00e1c d\u00f9 kh\u00f4ng c\u00f3 enzyme"},"content":{"rendered":"

2026-07-27 09:50 KST<\/strong><\/p>\n

Nghi\u00ean c\u1ee9u cho th\u1ea5y protein kh\u00f4ng c\u00f3 ch\u1ee9c n\u0103ng x\u00fac t\u00e1c v\u1eabn t\u0103ng t\u1ed1c ph\u1ea3n \u1ee9ng khi ng\u01b0ng t\u1ee5 th\u00e0nh gi\u1ecdt l\u1ecfng \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u0103ng sau ph\u1ea3n bi\u1ec7n tr\u00ean Molecular Cell.<\/p>\n

K\u1ebft qu\u1ea3 g\u1ee3i \u00fd ch\u1ea5t ng\u01b0ng t\u1ee5 sinh h\u1ecdc kh\u00f4ng m\u00e0ng kh\u00f4ng ch\u1ec9 gom ph\u00e2n t\u1eed; tr\u1ea1ng th\u00e1i ng\u01b0ng t\u1ee5 c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh ch\u1ea5t x\u00fac t\u00e1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 condenzyme.<\/p>\n

\u0110i\u1ec1u g\u00ec t\u1ea1o ph\u1ea3n \u1ee9ng<\/h2>\n

Nh\u00f3m t\u1ea1o ch\u1ea5t ng\u01b0ng t\u1ee5 t\u1eeb protein m\u1ea5t tr\u1eadt t\u1ef1 n\u1ed9i t\u1ea1i, kh\u00f4ng c\u00f3 c\u1ea5u tr\u00fac c\u1ed1 \u0111\u1ecbnh hay v\u1ecb tr\u00ed ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzyme. \u0110i\u1ec7n tr\u01b0\u1eddng b\u1ec1 m\u1eb7t v\u00e0 thay \u0111\u1ed5i t\u00ednh ch\u1ea5t n\u01b0\u1edbc t\u1ea1o m\u00f4i tr\u01b0\u1eddng th\u00fac \u0111\u1ea9y th\u1ee7y ph\u00e2n ester, ATP, c\u01a1 ch\u1ea5t gi\u1ed1ng acid nucleic v\u00e0 peptide.<\/p>\n

Th\u00e0nh ph\u1ea7n gi\u1ecdt quy\u1ebft \u0111\u1ecbnh ch\u1ee9c n\u0103ng<\/h2>\n

Kh\u00f4ng ph\u1ea3i m\u1ecdi ch\u1ea5t ng\u01b0ng t\u1ee5 \u0111\u1ec1u x\u00fac t\u00e1c nh\u01b0 nhau. Thay tr\u00ecnh t\u1ef1 v\u00e0 ph\u00e2n b\u1ed1 \u0111i\u1ec7n t\u00edch l\u00e0m \u0111\u1ed5i \u0111i\u1ec7n tr\u01b0\u1eddng, ho\u1ea1t \u0111\u1ed9 n\u01b0\u1edbc v\u00e0 t\u1ed1c \u0111\u1ed9 ph\u1ea3n \u1ee9ng. Thi\u1ebft k\u1ebf tr\u00ecnh t\u1ef1 c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c t\u00ednh ch\u1ea5t \u0111i\u1ec7n h\u00f3a n\u00e0y.<\/p>\n

\"H\u00ecnh
H\u00ecnh minh h\u1ecda do ONEPRESS t\u1ea1o: m\u00f4 t\u1ea3 x\u00fac t\u00e1c t\u1ea1i b\u1ec1 m\u1eb7t ch\u1ea5t ng\u01b0ng t\u1ee5, kh\u00f4ng ph\u1ea3i \u1ea3nh hi\u1ec3n vi th\u1eadt.<\/figcaption><\/figure>\n

T\u00e1c \u0111\u1ed9ng xu\u1ea5t hi\u1ec7n trong vi khu\u1ea9n s\u1ed1ng<\/h2>\n

Ch\u1ea5t ng\u01b0ng t\u1ee5 t\u1ed5ng h\u1ee3p \u0111\u01b0a v\u00e0o E. coli l\u00e0m \u0111\u1ed5i ATP, phi\u00ean m\u00e3 v\u00e0 b\u1eadt m\u1ea1ch gene ph\u1ee5 thu\u1ed9c s\u1ea3n ph\u1ea9m th\u1ee7y ph\u00e2n. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y h\u00f3a h\u1ecdc c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng m\u1ed9t h\u1ec7 t\u1ebf b\u00e0o s\u1ed1ng.<\/p>\n

B\u1ec7nh ng\u01b0\u1eddi v\u00e0 \u0111i\u1ec1u tr\u1ecb v\u1eabn ch\u01b0a r\u00f5<\/h2>\n

Th\u00ed nghi\u1ec7m ch\u00ednh d\u00f9ng protein tinh s\u1ea1ch v\u00e0 vi khu\u1ea9n thi\u1ebft k\u1ebf. Ch\u01b0a bi\u1ebft ch\u1ea5t ng\u01b0ng t\u1ee5 t\u1ef1 nhi\u00ean trong t\u1ebf b\u00e0o ng\u01b0\u1eddi \u0111i\u1ec1u khi\u1ec3n ph\u1ea3n \u1ee9ng n\u00e0o. Li\u00ean h\u1ec7 v\u1edbi ung th\u01b0 hay tho\u00e1i h\u00f3a th\u1ea7n kinh l\u00e0 gi\u1ea3 thuy\u1ebft, kh\u00f4ng ph\u1ea3i k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Ph\u1ea1m vi ch\u00ednh x\u00e1c c\u1ee7a t\u00ednh m\u1edbi<\/h2>\n

B\u1ea3n ti\u1ec1n c\u00f4ng b\u1ed1 \u0111\u00e3 c\u00f3 t\u1eeb 2024-2025. \u0110i\u1ec3m m\u1edbi l\u00e0 xu\u1ea5t b\u1ea3n ph\u1ea3n bi\u1ec7n cu\u1ed1i c\u00f9ng ng\u00e0y 24 th\u00e1ng 7 n\u0103m 2026. B\u01b0\u1edbc ti\u1ebfp theo l\u00e0 \u0111o quan h\u1ec7 nh\u00e2n qu\u1ea3 trong ch\u1ea5t ng\u01b0ng t\u1ee5 t\u1ef1 nhi\u00ean.<\/p>\n

Ngu\u1ed3n s\u01a1 c\u1ea5p ch\u00ednh th\u1ee9c<\/h2>\n

Washington University: Molecular Cell publication and experiment summary<\/a><\/p>\n

Molecular Cell: final peer-reviewed paper DOI<\/a><\/p>\n

bioRxiv: authors\u2019 detailed methods and experimental results<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Protein m\u1ea5t tr\u1eadt t\u1ef1 kh\u00f4ng c\u00f3 v\u1ecb tr\u00ed x\u00fac t\u00e1c v\u1eabn th\u00fac \u0111\u1ea9y th\u1ee7y ph\u00e2n ATP, c\u01a1 ch\u1ea5t gi\u1ed1ng acid nucleic v\u00e0 ph\u00e2n t\u1eed kh\u00e1c khi t\u1ea1o gi\u1ecdt ng\u01b0ng t\u1ee5. K\u1ebft qu\u1ea3 \u0111\u00e3 ph\u1ea3n bi\u1ec7n nh\u01b0ng ch\u1ee7 y\u1ebfu d\u1ef1a tr\u00ean protein tinh s\u1ea1ch v\u00e0 h\u1ec7 vi khu\u1ea9n t\u1ed5ng h\u1ee3p.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-888","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}