{"id":841,"date":"2026-07-26T08:40:00","date_gmt":"2026-07-25T23:40:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-07-26-scn2a-personalized-aso-zh\/"},"modified":"2026-07-26T08:48:52","modified_gmt":"2026-07-25T23:48:52","slug":"2026-07-26-scn2a-personalized-aso-zh","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-07-26-scn2a-personalized-aso-zh\/","title":{"rendered":"\u4e3a\u4e24\u540d\u60a3\u8005\u5206\u522b\u5b9a\u5236\u6cbb\u7597\uff0c\u766b\u75eb\u53d1\u4f5c\u51cf\u5c1126%\u548c90%"},"content":{"rendered":"<p><strong>2026-07-26 08:40 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class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/onepress.co.kr\/wp-content\/uploads\/2026\/07\/scn2a-personalized-aso-zh.png\" alt=\"\u5c55\u793a\u4e2a\u4f53\u5316ASO\u6291\u5236\u7a81\u53d8SCN2A\u526f\u672cRNA\u5e76\u4fdd\u7559\u6b63\u5e38\u526f\u672c\u529f\u80fd\u7684\u5236\u4f5c\u79d1\u5b66\u56fe\u7247\" loading=\"lazy\" \/><figcaption class=\"op-briefing-image-caption\">\u5236\u4f5c\u56fe\u7247\uff1aONEPRESS\u7528\u4e8e\u8bf4\u660e\u4e2a\u4f53\u5316ASO\u5982\u4f55\u9009\u62e9\u6027\u964d\u4f4e\u7a81\u53d8\u57fa\u56e0\u526f\u672c\u7684\u8868\u8fbe\u3002\u5b83\u4e0d\u662f\u771f\u5b9e\u60a3\u8005\u6216\u6cbb\u7597\u573a\u666f\u3002<\/figcaption><\/figure>\n<h2>\u7f55\u89c1\u75c5\u836f\u7269\u5f00\u53d1\u7f29\u5c0f\u5230\u4e2a\u4eba<\/h2>\n<p>\u8fd9\u79cd\u6a21\u5f0f\u4e0d\u662f\u4e3a\u540c\u4e00\u8bca\u65ad\u7684\u6240\u6709\u4eba\u5236\u9020\u4e00\u79cd\u836f\uff0c\u800c\u662f\u56f4\u7ed5\u4e00\u4e2a\u4eba\u7684\u57fa\u56e0\u7ec4\u8bbe\u8ba1\u548c\u6d4b\u8bd5\u4ea7\u54c1\u3002\u5b83\u53ef\u80fd\u4e3a\u7f55\u89c1\u5230\u65e0\u6cd5\u8fdb\u884c\u5927\u578b\u8bd5\u9a8c\u7684\u7a81\u53d8\u5efa\u7acb\u8def\u5f84\u3002<\/p>\n<p>\u53e6\u4e00\u5a74\u513f\u961f\u5217\u4e2d\u7ea616%\u5177\u6709\u9002\u5408\u8fd9\u79cd\u8bbe\u8ba1\u7684\u90bb\u8fd1\u6807\u8bb0\u3002\u8fd9\u8bf4\u660e\u5b58\u5728\u6269\u5c55\u53ef\u80fd\uff0c\u4e0d\u4ee3\u8868\u5df2\u7ecf\u9002\u7528\u4e8e\u6240\u6709SCN2A\u60a3\u8005\u3002<\/p>\n<h2>\u4e3a\u4ec0\u4e48\u4e0d\u80fd\u63a8\u5e7f\u7ed3\u8bba<\/h2>\n<p>\u6bcf\u540d\u513f\u7ae5\u90fd\u4e0e\u81ea\u5df1\u6cbb\u7597\u524d\u7684\u72b6\u6001\u6bd4\u8f83\uff0c\u6ca1\u6709\u968f\u673a\u5316\u6216\u5bf9\u7167\u7ec4\u3002\u53d1\u80b2\u53d8\u5316\u65e0\u6cd5\u4e0e\u53d1\u4f5c\u51cf\u5c11\u3001\u836f\u7269\u8c03\u6574\u548c\u6210\u957f\u5b8c\u5168\u5206\u5f00\uff0c\u957f\u671f\u5b89\u5168\u6027\u4ecd\u9700\u968f\u8bbf\u3002<\/p>\n<p>\u7814\u7a76\u8bc1\u660e\u4e2a\u4f53\u5316\u6cbb\u7597\u53ef\u4ee5\u4ea7\u751f\u53ef\u6d4b\u91cf\u7684\u4e34\u5e8a\u53d8\u5316\uff0c\u4f46\u5c1a\u672a\u5efa\u7acb\u5e7f\u6cdb\u53ef\u7528\u7684\u6807\u51c6\u7597\u6cd5\u3002<\/p>\n<h2>\u4e0b\u4e00\u6b65\u770b\u4ec0\u4e48<\/h2>\n<p>\u9700\u8981\u786e\u8ba4\u53d1\u4f5c\u548c\u53d1\u80b2\u6539\u5584\u662f\u5426\u6301\u7eed\u3001\u53cd\u590d\u9798\u5185\u7ed9\u836f\u7684\u957f\u671f\u5b89\u5168\u6027\uff0c\u4ee5\u53ca\u76f8\u540c\u8bbe\u8ba1\u65b9\u6cd5\u80fd\u591a\u5feb\u6269\u5c55\u5230\u66f4\u591a\u9057\u4f20\u75c5\u3002<\/p>\n<h2>\u5b98\u65b9\u4e00\u624b\u8d44\u6599<\/h2>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42481851\/\" target=\"_blank\" rel=\"noopener noreferrer\">Nature Medicine \/ PubMed original study<\/a><\/p>\n<p><a href=\"https:\/\/radygenomics.org\/2026\/personalized-gene-therapy-helps-teen-with-rare-form-of-severe-epilepsy-walk-independently\/\" target=\"_blank\" rel=\"noopener noreferrer\">Rady Children&#8217;s Institute for Genomic Medicine study release<\/a><\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06314490\" target=\"_blank\" rel=\"noopener noreferrer\">ClinicalTrials.gov NCT06314490<\/a><\/p>\n<p><a href=\"https:\/\/www.cirm.ca.gov\/clinical-trial\/personalized-antisense-oligonucleotide-therapy-for-rare-pediatric-genetic-disease-scn2a\/\" target=\"_blank\" rel=\"noopener noreferrer\">California Institute for Regenerative Medicine trial record<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e24\u540d\u60a3\u6709SCN2A\u76f8\u5173\u4e25\u91cd\u53d1\u80b2\u6027\u766b\u75eb\u6027\u8111\u75c5\u7684\u513f\u7ae5\uff0c\u5206\u522b\u63a5\u53d7\u9488\u5bf9\u81ea\u8eab\u7a81\u53d8\u57fa\u56e0\u526f\u672c\u8bbe\u8ba1\u7684ASO\u3002\u4e24\u5e74\u5185\u53d1\u4f5c\u9891\u7387\u4e0b\u964d26%\u548c90%\uff0c\u4f46\u8fd9\u53ea\u662f\u4e24\u9879\u65e0\u5bf9\u7167n-of-1\u7814\u7a76\u3002<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-841","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}