{"id":2360,"date":"2026-09-29T01:17:00","date_gmt":"2026-09-28T16:17:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-29-metal-free-dual-imaging-en\/"},"modified":"2026-09-29T13:25:05","modified_gmt":"2026-09-29T04:25:05","slug":"2026-09-29-metal-free-dual-imaging-en","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-29-metal-free-dual-imaging-en\/","title":{"rendered":"A metal-free molecule glowed red and enhanced MRI contrast"},"content":{"rendered":"

2026-09-29 01:17 KST<\/strong><\/p>\n

TTM-trisTP3B and TTM-trisTP9B emitted near 690 and 685 nm in water; the first remained fluorescent around living-cell nuclei for at least 24 hours.<\/p>\n

They improved T1 contrast in MRI phantoms about 2.5\u20134.5 times over earlier water-soluble TTM radicals. That comparison is not a clinical image-improvement rate.<\/p>\n

How one molecule serves two modes<\/h2>\n

Fluorescence uses absorbed and re-emitted light, while MRI reads changes in water-proton spin relaxation. Unpaired electrons in the radicals provide both luminescent and paramagnetic functions.<\/p>\n

Why water solubility matters<\/h2>\n

Earlier emitting TTM radicals were hydrophobic. Hydrophilic groups and adjusted donor positions preserved light emission and spin behaviour in water.<\/p>\n

\"A
This AI-generated image explains the topic; it is not a photograph of an actual event, observation or field site.<\/figcaption><\/figure>\n

Why this is not yet a gadolinium replacement<\/h2>\n

Removing metal opens a design route, but toxicity, distribution, clearance, dose, tissue contrast and long-term stability remain untested in animals and humans.<\/p>\n

What must be tested next<\/h2>\n

Animal imaging, pharmacokinetics, organ and immune toxicity, and performance at clinical magnetic fields must establish whether the dual probe is useful.<\/p>\n

Primary source and independent checks<\/h2>\n

Primary source: Advanced Science paper<\/a><\/p>\n

Institutional measurement or explanation: Kyushu University research release<\/a><\/p>\n

Independent check: PubMed bibliographic and abstract check<\/a><\/p>\n

Read in other languages<\/h2>\n

\ud55c\uad6d\uc5b4<\/a> \u00b7 English<\/a> \u00b7 Espa\u00f1ol<\/a> \u00b7 \u65e5\u672c\u8a9e<\/a> \u00b7 Ti\u1ebfng Vi\u1ec7t<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Two water-soluble organic radicals produced deep-red fluorescence and MRI contrast in laboratory tests. This is proof of concept in cells and MRI phantoms, not a contrast agent shown safe or effective in animals or people.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-2360","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/2360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=2360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}