{"id":2250,"date":"2026-09-25T01:11:00","date_gmt":"2026-09-24T16:11:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-25-psychad-brain-atlas-en\/"},"modified":"2026-09-25T01:11:00","modified_gmt":"2026-09-24T16:11:00","slug":"2026-09-25-psychad-brain-atlas-en","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-25-psychad-brain-atlas-en\/","title":{"rendered":"A human prefrontal-cortex atlas maps 6.32 million nuclei from 1,494 donors"},"content":{"rendered":"

2026-09-25 01:11 KST<\/strong><\/p>\n

The cohort spans ages 0\u2013108 and includes Alzheimer\u2019s, Parkinson\u2019s, schizophrenia, bipolar disorder and neurologically typical donors.<\/p>\n

Gene-activity changes tied to neuronal development and synaptic function overlapped especially strongly across dementias and Parkinson\u2019s disease.<\/p>\n

Why single nuclei<\/h2>\n

Whole-tissue averages hide rare cells and cell-type differences. Single-nucleus RNA analysis separates which genes change in which cell populations.<\/p>\n

6.32 million is not people<\/h2>\n

That is the number of nuclei after quality control; there were 1,494 unique donors. Calling it 6.32 million people would be wrong.<\/p>\n

\"A
This AI-generated image explains the topic; it is not a photograph of an actual event, observation or field site.<\/figcaption><\/figure>\n

What it enables<\/h2>\n

Researchers can examine disease-specific and shared cell changes and ancestry-linked genetic risk. Association does not prove a treatment target works or establish cause.<\/p>\n

Limits<\/h2>\n

Postmortem condition, diagnosis, medication and cause of death can affect results. Other regions, models, populations and functional tests are needed.<\/p>\n

Primary source and independent checks<\/h2>\n

Primary source: Nature cross-disorder paper<\/a><\/p>\n

Institutional explanation: Nature Portfolio programme summary<\/a><\/p>\n

Independent check: NIH\/PMC PsychAD cohort<\/a><\/p>\n

Read in other languages<\/h2>\n

\ud55c\uad6d\uc5b4<\/a> \u00b7 English<\/a> \u00b7 Espa\u00f1ol<\/a> \u00b7 \u65e5\u672c\u8a9e<\/a> \u00b7 Ti\u1ebfng Vi\u1ec7t<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

PsychAD analysed 6,320,459 quality-controlled nuclei from postmortem prefrontal cortex donated by 1,494 people across several brain disorders. It is not a diagnostic test for living people or proof of one cause for each disease.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-2250","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/2250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=2250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}