{"id":2082,"date":"2026-09-16T01:10:00","date_gmt":"2026-09-15T16:10:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-16-hidden-protein-variants-en\/"},"modified":"2026-09-16T01:10:00","modified_gmt":"2026-09-15T16:10:00","slug":"2026-09-16-hidden-protein-variants-en","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-16-hidden-protein-variants-en\/","title":{"rendered":"Researchers found 7,215 protein substitutions not fully visible from DNA alone"},"content":{"rendered":"

2026-09-16 01:10 KST<\/strong><\/p>\n

The Nature study published on 14 September 2026 shows that a human proteome can be more diverse than DNA-based prediction suggests. It grouped 13,910 confidently localized observations into 7,215 unique substitutions.<\/p>\n

Some arose from genetic or somatic variation; others were linked to alternate or erroneous translation. The study did not prove that every variant is functional or affects health.<\/p>\n

Data<\/h2>\n

The team integrated proteomic and genomic data from 29 healthy tissues and looked for reference and variant forms in the same proteome.<\/p>\n

Why DNA misses some<\/h2>\n

Cells translate RNA into amino-acid chains. A different amino acid can sometimes be inserted without a matching DNA change, leaving a protein difference invisible to genome sequencing alone.<\/p>\n

\"Researchers
This AI-generated image explains the topic; it is not a photograph of an actual patient, observation, field site or exhibition.<\/figcaption><\/figure>\n

Functional clues<\/h2>\n

Selected non-genetic substitutions were validated in purified proteins, and some recurred across people or fell at annotated functional sites. Recurrence alone is not proof of biological benefit or harm.<\/p>\n

Limits<\/h2>\n

Mass spectrometry can misassign similar signals, so strict filtering and replication matter. Most causes, tissue frequencies and disease links remain unresolved.<\/p>\n

Next check<\/h2>\n

Independent datasets, direct functional tests and studies across cell states are needed. The result expands the protein map; it does not yet change clinical testing.<\/p>\n

Primary source and independent checks<\/h2>\n

Nature \uc6d0 \ub17c\ubb38<\/a><\/p>\n

\uc2a4\ud398\uc778\uc5b4\uad8c \ub3c5\ub9bd \uacfc\ud559 \ud574\uc124<\/a><\/p>\n

Nature \ucd5c\uc2e0 \uc5f0\uad6c \ubaa9\ub85d<\/a><\/p>\n

Read in other languages<\/h2>\n

\ud55c\uad6d\uc5b4<\/a> \u00b7 English<\/a> \u00b7 Espa\u00f1ol<\/a> \u00b7 \u65e5\u672c\u8a9e<\/a> \u00b7 Ti\u1ebfng Vi\u1ec7t<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Across 29 healthy human tissues, researchers catalogued 7,215 unique single-amino-acid substitutions coexisting with reference proteins. This does not equal 7,215 new genes, disease causes or treatment targets.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-2082","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/2082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=2082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}