{"id":1983,"date":"2026-09-12T13:30:00","date_gmt":"2026-09-12T04:30:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-es\/"},"modified":"2026-09-12T13:30:00","modified_gmt":"2026-09-12T04:30:00","slug":"2026-09-12-wholistic-zebrafish-body-es","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-es\/","title":{"rendered":"Observaron actividad celular del cerebro al ri\u00f1\u00f3n en un pez cebra vivo"},"content":{"rendered":"<p><strong>2026-09-12 13:30 KST<\/strong><\/p>\n<p>WHOLISTIC registr\u00f3 a la vez actividad celular en cerebro, coraz\u00f3n, h\u00edgado, intestino, p\u00e1ncreas, ri\u00f1\u00f3n y circulaci\u00f3n de peces cebra j\u00f3venes vivos.<\/p>\n<p>La plataforma se prob\u00f3 en peces peque\u00f1os, transparentes y modificados para emitir fluorescencia; no est\u00e1 lista para uso cl\u00ednico humano.<\/p>\n<h2>Funcionamiento<\/h2>\n<p>Sensores de calcio brillan con la actividad; microscop\u00eda volum\u00e9trica r\u00e1pida y aprendizaje autom\u00e1tico ordenan espacio y tiempo.<\/p>\n<h2>Hallazgos<\/h2>\n<p>Aparecieron ondas en nefronas, cambios durante estados de sue\u00f1o, c\u00e9lulas que responden a ketamina y control del flujo sangu\u00edneo por el tronco cerebral.<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/onepress.co.kr\/wp-content\/uploads\/2026\/09\/wholistic-zebrafish-body-es.png\" alt=\"Observaron actividad celular del cerebro al ri\u00f1\u00f3n en un pez cebra vivo\" loading=\"lazy\" \/><figcaption class=\"op-briefing-image-caption\">Esta imagen generada por IA explica el tema; no es una fotograf\u00eda del lugar, experimento, animal o f\u00f3sil real.<\/figcaption><\/figure>\n<h2>Causa<\/h2>\n<p>La optogen\u00e9tica permiti\u00f3 probar si se\u00f1ales cerebrales causaban respuestas corporales y no solo coincid\u00edan.<\/p>\n<h2>L\u00edmites<\/h2>\n<p>\u201cCasi todo\u201d no es cada c\u00e9lula. Marcado, resoluci\u00f3n, luz e interpretaci\u00f3n limitan el resultado; el pez no equivale a humanos.<\/p>\n<h2>Siguiente paso<\/h2>\n<p>Modelos de enfermedad, inmunidad y f\u00e1rmacos deben comprobar qu\u00e9 circuitos se repiten.<\/p>\n<h2>Fuente primaria y comprobaciones independientes<\/h2>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-026-10979-6\" target=\"_blank\" rel=\"noopener noreferrer\">Nature \uc6d0 \ub17c\ubb38<\/a><\/p>\n<p><a href=\"https:\/\/wholistic.janelia.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">Janelia WHOLISTIC \uc790\ub8cc<\/a><\/p>\n<h2>Leer en otros idiomas<\/h2>\n<p><a href=\"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-ko\/\">\ud55c\uad6d\uc5b4<\/a> \u00b7 <a href=\"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-en\/\">English<\/a> \u00b7 <a href=\"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-es\/\">Espa\u00f1ol<\/a> \u00b7 <a href=\"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-ja\/\">\u65e5\u672c\u8a9e<\/a> \u00b7 <a href=\"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-vi\/\">Ti\u1ebfng Vi\u1ec7t<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>WHOLISTIC registra casi todo un pez cebra larvario transparente con resoluci\u00f3n celular y descubre se\u00f1ales entre \u00f3rganos. No es un esc\u00e1ner m\u00e9dico humano.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-1983","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/1983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=1983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}