{"id":1982,"date":"2026-09-12T13:30:00","date_gmt":"2026-09-12T04:30:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-en\/"},"modified":"2026-09-12T13:30:00","modified_gmt":"2026-09-12T04:30:00","slug":"2026-09-12-wholistic-zebrafish-body-en","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-12-wholistic-zebrafish-body-en\/","title":{"rendered":"Researchers watched cellular activity from brain to kidney across a living zebrafish"},"content":{"rendered":"

2026-09-12 13:30 KST<\/strong><\/p>\n

WHOLISTIC simultaneously recorded cellular activity across most of a living larval zebrafish, including brain, heart, liver, gut, pancreas, kidney and circulation. It narrows the gap between detailed single-organ and coarse whole-body imaging.<\/p>\n

The platform was validated in small, transparent, genetically fluorescent fish. It is not ready for clinical human imaging.<\/p>\n

How it works<\/h2>\n

Genetically encoded calcium sensors glow with activity; fast volumetric fluorescence microscopy and machine learning organize space and time.<\/p>\n

What appeared<\/h2>\n

The team saw waves along kidney nephrons, body-wide changes during sleep-like states, ketamine-responsive cells near the brain and brainstem control of blood redistribution.<\/p>\n

\"Researchers
This AI-generated image explains the topic; it is not a photograph of the actual site, experiment, animal or fossil.<\/figcaption><\/figure>\n

Testing cause<\/h2>\n

Optogenetic stimulation helped test whether brain signals caused body responses rather than merely occurring together.<\/p>\n

Limits<\/h2>\n

Most of the body is not every cell. Labelling, resolution, light exposure and interpretation constrain results, and fish findings do not transfer directly to humans.<\/p>\n

Next<\/h2>\n

Disease, immune and drug models must show which cross-organ circuits repeat and how live activity maps onto anatomy.<\/p>\n

Primary source and independent checks<\/h2>\n

Nature \uc6d0 \ub17c\ubb38<\/a><\/p>\n

Janelia WHOLISTIC \uc790\ub8cc<\/a><\/p>\n

Read in other languages<\/h2>\n

\ud55c\uad6d\uc5b4<\/a> \u00b7 English<\/a> \u00b7 Espa\u00f1ol<\/a> \u00b7 \u65e5\u672c\u8a9e<\/a> \u00b7 Ti\u1ebfng Vi\u1ec7t<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

WHOLISTIC records most of a transparent larval zebrafish at cellular resolution and reveals cross-organ signals. It is not a whole-body medical scanner for humans.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-1982","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/1982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=1982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}