{"id":1746,"date":"2026-09-03T06:03:00","date_gmt":"2026-09-02T21:03:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-03-functional-chimeric-mrna-immunity-vi\/"},"modified":"2026-09-03T06:03:00","modified_gmt":"2026-09-02T21:03:00","slug":"2026-09-03-functional-chimeric-mrna-immunity-vi","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-09-03-functional-chimeric-mrna-immunity-vi\/","title":{"rendered":"RNA t\u1eeb c\u00e1c gen \u1edf xa t\u1ea1o ra m\u1ed9t protein… L\u1edbp \u0111i\u1ec1u h\u00f2a \u1ea9n c\u1ee7a ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch"},"content":{"rendered":"

2026-09-03 06:03 KST<\/strong><\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i Tr\u01b0\u1eddng Y Harvard \u0111\u00e3 \u0111\u01b0a ra b\u1eb1ng ch\u1ee9ng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a chu\u1ed9t v\u00e0 th\u00ed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y c\u00e1c \u0111o\u1ea1n RNA t\u1eeb gen tr\u00ean c\u00e1c nhi\u1ec5m s\u1eafc th\u1ec3 kh\u00e1c nhau \u0111\u01b0\u1ee3c k\u1ebft n\u1ed1i ch\u00ednh x\u00e1c v\u00e0 mRNA kh\u1ea3m n\u00e0y t\u1ea1o ra c\u00e1c protein c\u00f3 ch\u1ee9c n\u0103ng ph\u1ea3n \u1ee9ng vi\u00eam. Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 ng\u00e0y 2 th\u00e1ng 9 tr\u00ean t\u1ea1p ch\u00ed Nature.<\/p>\n

Ch\u1ee9c n\u0103ng c\u1ee7a h\u00e0ng ng\u00e0n protein m\u1edbi \u1edf ng\u01b0\u1eddi v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn ho\u1eb7c c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi ch\u01b0a \u0111\u01b0\u1ee3c kh\u00e1m ph\u00e1. M\u1ed9t v\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh trong \u0111\u00f3 nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c minh s\u00e2u s\u1eafc ch\u1ee9c n\u0103ng c\u1ee7a n\u00f3 l\u00e0 ph\u1ee9c h\u1ee3p Gsdmd\u2013Tmem106a \u1edf chu\u1ed9t, v\u00e0 ph\u1ea1m vi c\u0169ng nh\u01b0 vai tr\u00f2 c\u1ee5 th\u1ec3 c\u1ee7a b\u1ec7nh trong t\u1ebf b\u00e0o ng\u01b0\u1eddi v\u1eabn c\u00f2n \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn th\u00eam.<\/p>\n

C\u00f3 g\u00ec kh\u00e1c v\u1edbi l\u1eddi gi\u1ea3i th\u00edch tr\u01b0\u1edbc \u0111\u00f3?<\/h2>\n

Th\u00f4ng th\u01b0\u1eddng, ch\u00fang ta bi\u1ebft r\u1eb1ng m\u1ed9t mRNA tr\u01b0\u1edfng th\u00e0nh \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch n\u1ed1i c\u00e1c exon c\u1ee7a m\u1ed9t locus gen. Trong nghi\u00ean c\u1ee9u n\u00e0y, b\u1ea3n sao c\u1ee7a c\u00e1c gen c\u00f3 quan h\u1ec7 xa v\u1edbi nhau, \u0111\u00f4i khi t\u1eeb c\u00e1c nhi\u1ec5m s\u1eafc th\u1ec3 kh\u00e1c nhau, \u0111\u01b0\u1ee3c n\u1ed1i v\u1edbi nhau b\u1eb1ng c\u00e1ch gh\u00e9p n\u1ed1i. Kh\u00f4ng gi\u1ed1ng nh\u01b0 s\u1ef1 h\u1ee3p nh\u1ea5t gen ung th\u01b0, v\u1ed1n l\u00e0 s\u1ef1 h\u1ee3p nh\u1ea5t c\u1ee7a ch\u00ednh DNA, \u0111\u00e2y l\u00e0 nh\u1eefng s\u1ef1 k\u1ebft h\u1ee3p x\u1ea3y ra \u1edf c\u1ea5p \u0111\u1ed9 RNA trong ph\u1ea3n \u1ee9ng vi\u00eam th\u00f4ng th\u01b0\u1eddng.<\/p>\n

C\u00e1ch l\u1ecdc t\u00edn hi\u1ec7u r\u00e0ng bu\u1ed9c gi\u1ea3<\/h2>\n

\u0110\u1ec3 tr\u00e1nh s\u1ef1 k\u1ebft h\u1ee3p nh\u00e2n t\u1ea1o c\u00f3 th\u1ec3 x\u1ea3y ra trong qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p cDNA, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eed d\u1ee5ng tr\u00ecnh t\u1ef1 l\u1ed7 nano \u0111\u1ec3 \u0111\u1ecdc tr\u1ef1c ti\u1ebfp c\u00e1c ph\u00e2n t\u1eed RNA. Ch\u00fang t\u00f4i \u0111\u00e3 thu \u0111\u01b0\u1ee3c 52,9 tri\u1ec7u l\u01b0\u1ee3t \u0111\u1ecdc chuy\u1ec3n ti\u1ebfp t\u1eeb 10 l\u1ea7n sao ch\u00e9p sinh h\u1ecdc trong c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ee7y x\u01b0\u01a1ng chu\u1ed9t v\u00e0 c\u00e1c \u1ee9ng c\u1eed vi\u00ean l\u1eb7p l\u1ea1i \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn b\u1eb1ng c\u00e1ch \u0111\u1ecdc ng\u1eafn, NanoString, PCR, ph\u00e2n t\u00edch protein v\u00e0 ch\u1ec9nh s\u1eeda gen.<\/p>\n

\"RNA
\u0110\u00e2y l\u00e0 h\u00ecnh \u1ea3nh t\u1ea1o b\u1eb1ng AI \u0111\u1ec3 gi\u1ea3i th\u00edch ch\u1ee7 \u0111\u1ec1, kh\u00f4ng ph\u1ea3i \u1ea3nh ch\u1ee5p s\u1ef1 ki\u1ec7n, quan s\u00e1t hay th\u00ed nghi\u1ec7m th\u1ef1c t\u1ebf.<\/figcaption><\/figure>\n

C\u00e1c protein \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u0111\u00e3 l\u00e0m g\u00ec?<\/h2>\n

Protein \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch k\u1ebft h\u1ee3p Gsdmd v\u00e0 Tmem106a RNA \u0111\u00e3 c\u01b0 tr\u00fa trong m\u00e0ng t\u1ebf b\u00e0o v\u00e0 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh c\u00e1c l\u1ed7 vi\u00eam v\u00e0 gi\u1ea3i ph\u00f3ng IL-1\u03b2. Nh\u1eefng con chu\u1ed9t \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf li\u00ean h\u1ee3p n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng nhi\u1ec5m tr\u00f9ng huy\u1ebft g\u00e2y t\u1eed vong cao h\u01a1n, nh\u01b0ng kh\u1ea3 n\u0103ng ph\u00f2ng v\u1ec7 c\u1ee7a vi khu\u1ea9n b\u1ecb suy y\u1ebfu v\u00e0 khi ch\u00fang \u0111\u01b0\u1ee3c t\u1ea1o ra v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u1edbn, kh\u1ea3 n\u0103ng ph\u00f2ng v\u1ec7 c\u1ee7a ch\u00fang \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n nh\u01b0ng t\u1ef7 l\u1ec7 t\u1eed vong do nhi\u1ec5m tr\u00f9ng huy\u1ebft c\u0169ng t\u0103ng l\u00ean. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 l\u1ee3i \u00edch v\u00e0 t\u1ed5n th\u1ea5t c\u1ee7a kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh c\u00f9ng nhau.<\/p>\n

N\u00ean \u0111\u1ecdc c\u1ee5m t\u1eeb \u201cngh\u00ecn\u201d nh\u01b0 th\u1ebf n\u00e0o?<\/h2>\n

Quy tr\u00ecnh ph\u00e2n t\u00edch \u0111\u00e3 ph\u00e1t hi\u1ec7n 30.390 RNA kh\u1ea3m exon-exon \u0111\u1ec3 nghi\u00ean c\u1ee9u th\u00eam. Nh\u01b0ng \u0111i\u1ec1u \u0111\u00f3 kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 t\u1ea5t c\u1ea3 ch\u00fang \u0111\u1ec1u t\u1ea1o ra protein ho\u1eb7c c\u00f3 ch\u1ee9c n\u0103ng. Gi\u1ed1ng nh\u01b0 c\u00e1c li\u00ean h\u1ee3p \u0111\u1ea1i di\u1ec7n, s\u1ed1 l\u01b0\u1ee3ng protein m\u1edbi kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn trong ti\u00eau \u0111\u1ec1 v\u00ec t\u00ednh th\u1ef1c t\u1ebf, s\u1ef1 d\u1ecbch m\u00e3, v\u1ecb tr\u00ed t\u1ebf b\u00e0o v\u00e0 ch\u1ee9c n\u0103ng \u0111\u1ed9ng v\u1eadt c\u1ee7a RNA ph\u1ea3i \u0111\u01b0\u1ee3c x\u00e1c minh ri\u00eang bi\u1ec7t.<\/p>\n

Nghi\u00ean c\u1ee9u ti\u1ebfp theo n\u00ean tr\u1ea3 l\u1eddi \u0111i\u1ec1u g\u00ec?<\/h2>\n

C\u00e1c c\u00e2u h\u1ecfi ch\u00ednh l\u00e0 nh\u1eefng t\u00edn hi\u1ec7u n\u00e0o mang c\u00e1c gen nh\u1ea5t \u0111\u1ecbnh l\u1ea1i v\u1edbi nhau trong nh\u00e2n, t\u1ea1i sao c\u00e1c \u0111i\u1ec3m li\u00ean k\u1ebft c\u1ee7a ch\u00fang l\u1ea1i ch\u00ednh x\u00e1c v\u00e0 ch\u00fang \u0111\u01b0\u1ee3c b\u1ea3o t\u1ed3n nh\u01b0 th\u1ebf n\u00e0o trong c\u00e1c m\u00f4 v\u00e0 b\u1ec7nh b\u00ecnh th\u01b0\u1eddng c\u1ee7a con ng\u01b0\u1eddi. Nh\u1eafm m\u1ee5c ti\u00eau tr\u1ecb li\u1ec7u c\u0169ng y\u00eau c\u1ea7u \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00e1c t\u00e1c d\u1ee5ng mi\u1ec5n d\u1ecbch mong mu\u1ed1n c\u00f3 th\u1ec3 t\u00e1ch bi\u1ec7t kh\u1ecfi c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5, ch\u1eb3ng h\u1ea1n nh\u01b0 nhi\u1ec5m tr\u00f9ng huy\u1ebft.<\/p>\n

Ngu\u1ed3n g\u1ed1c v\u00e0 ki\u1ec3m ch\u1ee9ng \u0111\u1ed9c l\u1eadp<\/h2>\n

Nature \uc6d0 \ub17c\ubb38<\/a><\/p>\n

Harvard Medical School \uc5f0\uad6c \uc124\uba85<\/a><\/p>\n

Laborwelt\uc758 \ub3c5\ub9bd \ub3c5\uc77c\uc5b4 \uacfc\ud559 \ubcf4\ub3c4<\/a><\/p>\n

Nature \uac19\uc740 \ud638 \uc5f0\uad6c \ubaa9\ub85d\uc758 \ub3c5\ub9bd \uc0c9\uc778<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c nh\u1eadn \u1edf \u0111\u1ea1i th\u1ef1c b\u00e0o chu\u1ed9t hi\u1ec7n t\u01b0\u1ee3ng RNA t\u1eeb c\u00e1c gen kh\u00e1c nhau \u0111\u01b0\u1ee3c k\u1ebft n\u1ed1i \u0111\u1ec3 t\u1ea1o ra m\u1ed9t protein ch\u1ee9c n\u0103ng. \u0110i\u1ec1u n\u00e0y kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 b\u1ea3n \u0111\u1ed3 protein c\u1ee7a con ng\u01b0\u1eddi ngay l\u1eadp t\u1ee9c t\u0103ng l\u00ean h\u00e0ng ngh\u00ecn.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-1746","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/1746","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=1746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}