{"id":1581,"date":"2026-08-29T05:54:00","date_gmt":"2026-08-28T20:54:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-08-29-self-assembled-peptide-nanopores-vi\/"},"modified":"2026-08-29T05:54:00","modified_gmt":"2026-08-28T20:54:00","slug":"2026-08-29-self-assembled-peptide-nanopores-vi","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-08-29-self-assembled-peptide-nanopores-vi\/","title":{"rendered":"T\u00e1m peptide gi\u1ed1ng h\u1ec7t nhau t\u1ea1o ra c\u00e1c l\u1ed7 c\u00f3 hai k\u00edch c\u1ee1 v\u00e0 h\u00ecnh d\u1ea1ng h\u1ed7n h\u1ee3p c\u1ee7a c\u00e1c protein b\u1ec7nh \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i b\u1eb1ng d\u00f2ng \u0111i\u1ec7n."},"content":{"rendered":"

2026-08-29 05:54 KST<\/strong><\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb \u1ea4n \u0110\u1ed9 v\u00e0 \u0110\u1ee9c \u0111\u00e3 c\u00f4ng b\u1ed1 k\u1ebft qu\u1ea3 cho th\u1ea5y 8 peptide ng\u1eafn gi\u1ed1ng h\u1ec7t nhau t\u1ef1 l\u1eafp r\u00e1p th\u00e0nh hai tr\u1ea1ng th\u00e1i nh\u1ecf v\u00e0 l\u1edbn trong m\u00e0ng v\u00e0 h\u00ecnh d\u1ea1ng c\u1ee7a \u0111\u01b0\u1eddng, peptide v\u00e0 protein li\u00ean quan \u0111\u1ebfn b\u1ec7nh t\u1eadt c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e2n bi\u1ec7t d\u1ef1a tr\u00ean d\u1ea5u v\u1ebft d\u00f2ng \u0111i\u1ec7n c\u1ee7a c\u00e1c ph\u00e2n t\u1eed \u0111i qua ch\u00fang. Trong th\u00ed nghi\u1ec7m, c\u00e1c l\u1ed7 l\u1edbn ph\u00e2n bi\u1ec7t c\u00e1c bi\u1ebfn th\u1ec3 alpha-synuclein li\u00ean quan \u0111\u1ebfn b\u1ec7nh Parkinson v\u00e0 c\u00e1c giai \u0111o\u1ea1n k\u1ebft t\u1ee5 kh\u00e1c nhau.<\/p>\n

\u0110i\u1ec1u n\u00e0y kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 b\u00e2y gi\u1edd ch\u00fang ta c\u00f3 th\u1ec3 ch\u1ea9n \u0111o\u00e1n b\u1ec7nh Parkinson hay b\u1ec7nh Lou Gehrig ch\u1ec9 b\u1eb1ng m\u1ed9t gi\u1ecdt m\u00e1u. \u0110\u00e2y l\u00e0 m\u1ed9t th\u00ed nghi\u1ec7m ph\u00e2n t\u1eed \u0111\u01a1n l\u1ebb \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean protein tinh khi\u1ebft v\u00e0 m\u00e0ng lipid nh\u00e2n t\u1ea1o, c\u00e1c th\u00e0nh ph\u1ea7n ph\u1ee9c t\u1ea1p c\u1ee7a m\u00e1u th\u1eadt, t\u1ef7 l\u1ec7 ph\u00e1t hi\u1ec7n sai, \u0111\u1ed9 l\u1eb7p l\u1ea1i v\u00e0 kh\u1ea3 n\u0103ng ph\u00e2n bi\u1ec7t gi\u1eefa c\u00e1c b\u1ec7nh nh\u00e2n ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c minh.<\/p>\n

C\u00e1i l\u1ed7 \u0111\u00e3 t\u1ef1 t\u1ea1o ra nh\u01b0 th\u1ebf n\u00e0o?<\/h2>\n

T\u00e1m peptide pPorA g\u1ed3m 40 axit amin k\u1ebft h\u1ee3p v\u1edbi nhau \u0111\u1ec3 t\u1ea1o ra m\u1ed9t \u0111\u01b0\u1eddng xo\u1eafn \u1ed1c xuy\u00ean qua m\u00e0ng. C\u00f9ng m\u1ed9t octamer cho th\u1ea5y tr\u1ea1ng th\u00e1i nh\u1ecf 2,4 nanosiemen v\u00e0 tr\u1ea1ng th\u00e1i l\u1edbn 3,5 nanosiemen \u1edf t\u1ea7n s\u1ed1 t\u01b0\u01a1ng t\u1ef1 trong \u0111i\u1ec1u ki\u1ec7n 1 mol kali clorua. H\u00ecnh d\u1ea1ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u0169ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1eb1ng c\u00e1ch thay \u0111\u1ed5i axit amin \u1edf m\u1ed9t v\u1ecb tr\u00ed c\u1ee5 th\u1ec3.<\/p>\n

B\u1ea1n \u0111\u00e3 ph\u00e2n bi\u1ec7t \u0111\u01b0\u1ee3c \u0111i\u1ec1u g\u00ec?<\/h2>\n

C\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u1edf ch\u1ed7 \u0111\u01b0\u1eddng l\u1edbn b\u00e1m v\u00e0o c\u00e1c l\u1ed7 nh\u1ecf nh\u01b0ng kh\u00f4ng xuy\u00ean qua ch\u00fang, trong khi ch\u00fang l\u1ea1i xuy\u00ean qua c\u00e1c l\u1ed7 l\u1edbn. C\u00e1c l\u1ed7 ch\u00e2n l\u00f4ng l\u1edbn ph\u00e2n bi\u1ec7t m\u1ed9t s\u1ed1 bi\u1ebfn th\u1ec3 alpha-synuclein v\u00e0 c\u00e1c giai \u0111o\u1ea1n \u0111\u01a1n ph\u00e2n, oligomeric v\u00e0 fibrillar b\u1eb1ng m\u1ee9c \u0111\u1ed9 v\u00e0 th\u1eddi gian t\u1eafc ngh\u1ebdn hi\u1ec7n t\u1ea1i. L\u1ed7 ch\u00e2n l\u00f4ng nh\u1ecf ph\u00e1t hi\u1ec7n c\u00e1c peptide nh\u1ecf li\u00ean quan \u0111\u1ebfn humanin v\u00e0 SOD1.<\/p>\n

\"T\u00e1m
\u0110\u00e2y l\u00e0 h\u00ecnh \u1ea3nh t\u1ea1o b\u1eb1ng AI \u0111\u1ec3 gi\u1ea3i th\u00edch ch\u1ee7 \u0111\u1ec1, kh\u00f4ng ph\u1ea3i \u1ea3nh ch\u1ee5p s\u1ef1 ki\u1ec7n, quan s\u00e1t hay th\u00ed nghi\u1ec7m th\u1ef1c t\u1ebf.<\/figcaption><\/figure>\n

20 nanomole c\u00f3 ngh\u0129a l\u00e0 g\u00ec?<\/h2>\n

B\u00e0i b\u00e1o \u0111\u00e3 b\u00e1o c\u00e1o \u00e1i l\u1ef1c g\u1eafn k\u1ebft kho\u1ea3ng 20 nanomol v\u1edbi bi\u1ebfn th\u1ec3 alpha-synuclein x\u00f3a \u0111\u1ea7u C li\u00ean quan \u0111\u1ebfn b\u1ec7nh Parkinson. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y l\u1ed7 ch\u00e2n l\u00f4ng v\u00e0 protein t\u01b0\u01a1ng t\u00e1c t\u1ed1t nh\u01b0 th\u1ebf n\u00e0o trong \u0111i\u1ec1u ki\u1ec7n tinh ch\u1ebf. Kh\u00f4ng ph\u1ea3i t\u1ef7 l\u1ec7 ph\u1ea7n tr\u0103m m\u00e1u c\u1ee7a b\u1ec7nh nh\u00e2n kh\u00f4ng b\u1ecf s\u00f3t b\u1ec7nh hay con s\u1ed1 ch\u00ednh x\u00e1c n\u00e0o x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh.<\/p>\n

T\u1ea1i sao c\u1ea3 hai k\u00edch th\u01b0\u1edbc \u0111\u1ec1u h\u1eefu \u00edch?<\/h2>\n

N\u1ebfu k\u00eanh ch\u1ec9 c\u00f3 m\u1ed9t k\u00edch th\u01b0\u1edbc c\u1ed1 \u0111\u1ecbnh th\u00ec c\u00e1c protein c\u00f3 h\u00ecnh d\u1ea1ng kh\u00e1c nhau s\u1ebd ch\u1ec9 \u0111\u01b0\u1ee3c \u0111\u1ecdc theo m\u1ed9t c\u00e1ch. N\u1ebfu c\u00e1c th\u00e0nh ph\u1ea7n gi\u1ed1ng nhau t\u1ea1o n\u00ean c\u1ea3 hai \u0111\u01b0\u1eddng k\u00ednh, t\u00edn hi\u1ec7u c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e2n t\u00e1ch \u0111\u1ec3 ch\u1ee9a c\u00e1c protein l\u1edbn v\u00e0 c\u00e1c peptide nh\u1ecf. Tuy nhi\u00ean, c\u00e1c ph\u00e9p t\u00ednh \u0111\u1ed9ng l\u1ef1c ph\u00e2n t\u1eed c\u00f3 h\u1ea1n ch\u1ebf \u1edf ch\u1ed7 ch\u00fang s\u1eed d\u1ee5ng c\u00e1c \u0111o\u1ea1n \u0111\u01a1n gi\u1ea3n v\u00e0 \u0111i\u1ec7n tr\u01b0\u1eddng cao.<\/p>\n

X\u00e1c minh ti\u1ebfp theo l\u00e0 g\u00ec?<\/h2>\n

T\u00ednh ch\u1ecdn l\u1ecdc, \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh l\u00e2u d\u00e0i c\u1ee7a m\u00e0ng v\u00e0 c\u00e1c bi\u1ebfn th\u1ec3 s\u1ea3n xu\u1ea5t ph\u1ea3i \u0111\u01b0\u1ee3c ki\u1ec3m tra trong mu\u1ed1i sinh l\u00fd v\u00e0 d\u1ecbch c\u01a1 th\u1ec3 th\u1ef1c. Ch\u1ec9 sau khi s\u00e0ng l\u1ecdc c\u00e1c nh\u00f3m b\u1ec7nh nh\u00e2n kh\u00e1c nhau v\u00e0 ti\u1ebft l\u1ed9 \u0111\u1ed9 nh\u1ea1y v\u00e0 \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u th\u00ec kh\u1ea3 n\u0103ng ch\u1ea9n \u0111o\u00e1n m\u1edbi c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh. Gi\u00e1 tr\u1ecb c\u1ee7a b\u01b0\u1edbc n\u00e0y n\u1eb1m \u1edf vi\u1ec7c t\u1ea1o ra m\u1ed9t n\u1ec1n t\u1ea3ng c\u1ea3m bi\u1ebfn g\u1ecdi l\u00e0 l\u1ed7 peptit xo\u1eafn \u1ed1c linh ho\u1ea1t.<\/p>\n

Ngu\u1ed3n g\u1ed1c v\u00e0 ki\u1ec3m ch\u1ee9ng \u0111\u1ed9c l\u1eadp<\/h2>\n

Nature Nanotechnology original paper<\/a><\/p>\n

RGCB independent conference abstract record<\/a><\/p>\n

Open data record on Zenodo<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00e1m peptide pPorA \u0111\u00e3 t\u1ea1o ra hai tr\u1ea1ng th\u00e1i l\u1ed7 nano l\u00e0 2,4 v\u00e0 3,5 nanosiemens. M\u1eb7c d\u00f9 c\u00e1c giai \u0111o\u1ea1n t\u1eadp h\u1ee3p v\u00e0 \u0111\u1ed9t bi\u1ebfn alpha-synuclein \u0111\u01b0\u1ee3c ph\u00e2n bi\u1ec7t trong \u1ed1ng nghi\u1ec7m nh\u01b0ng n\u00f3 kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t c\u00f4ng c\u1ee5 ch\u1ea9n \u0111o\u00e1n l\u00e2m s\u00e0ng.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-1581","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/1581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=1581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}