{"id":1419,"date":"2026-08-24T17:40:00","date_gmt":"2026-08-24T08:40:00","guid":{"rendered":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-08-24-five-year-brain-organoids-clock-vi\/"},"modified":"2026-08-24T17:40:00","modified_gmt":"2026-08-24T08:40:00","slug":"2026-08-24-five-year-brain-organoids-clock-vi","status":"publish","type":"briefing","link":"https:\/\/onepress.co.kr\/index.php\/briefing\/2026-08-24-five-year-brain-organoids-clock-vi\/","title":{"rendered":"M\u1ed9t kh\u1ed1i t\u1ebf b\u00e0o n\u00e3o nh\u1ecf trong chi\u1ebfc \u0111\u0129a \u0111\u00e3 ghi nh\u1edb \u0111\u01b0\u1ee3c 5 n\u0103m nh\u01b0ng n\u00f3 ch\u01b0a ph\u1ea3i l\u00e0 m\u1ed9t b\u1ed9 n\u00e3o ho\u00e0n ch\u1ec9nh."},"content":{"rendered":"

2026-08-24 17:40 KST<\/strong><\/p>\n

Khi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u nu\u00f4i c\u1ea5y m\u1ed9t m\u00f4 h\u00ecnh t\u1ebf b\u00e0o v\u1ecf n\u00e3o nh\u1ecf \u0111\u01b0\u1ee3c l\u00e0m t\u1eeb t\u1ebf b\u00e0o g\u1ed1c c\u1ee7a con ng\u01b0\u1eddi trong h\u01a1n 5 n\u0103m, ho\u1ea1t \u0111\u1ed9ng gen v\u00e0 d\u1ea5u hi\u1ec7u DNA c\u1ee7a t\u1ebf b\u00e0o \u0111\u00e3 tr\u01b0\u1edfng th\u00e0nh theo th\u1eddi gian th\u1ef1c t\u1ebf \u0111\u00e3 tr\u00f4i qua. C\u00e1c t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n l\u00e2u n\u0103m c\u0169ng b\u1ecf qua nh\u1eefng giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n m\u00e0 ch\u00fang \u0111\u00e3 tr\u1ea3i qua.<\/p>\n

M\u1eb7c d\u00f9 nh\u1eefng m\u00f4 h\u00ecnh t\u1ebf b\u00e0o n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 c\u00e1c c\u01a1 quan n\u00e3o nh\u01b0ng ch\u00fang kh\u00f4ng ph\u1ea3i l\u00e0 b\u1ed9 n\u00e3o ho\u00e0n ch\u1ec9nh. N\u00f3 thi\u1ebfu m\u1ea1ch m\u00e1u, \u0111\u1ea7u v\u00e0o c\u1ea3m gi\u00e1c v\u00e0 nhi\u1ec1u m\u00f4 c\u1ee7a c\u01a1 th\u1ec3, m\u1ed9t s\u1ed1 t\u1ebf b\u00e0o th\u1ea7n kinh b\u1ecb thu nh\u1ecf trong qu\u00e1 tr\u00ecnh nu\u00f4i c\u1ea5y n\u1ed9i t\u1ea1ng v\u00e0 nghi\u00ean c\u1ee9u kh\u00f4ng \u0111o l\u01b0\u1eddng \u00fd th\u1ee9c hay suy ngh\u0129.<\/p>\n

b\u1ea1n \u0111\u00e3 quan s\u00e1t bao l\u00e2u<\/h2>\n

Ph\u00e2n t\u00edch m\u1edbi bao g\u1ed3m 34 c\u01a1 quan \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y t\u1eeb 6 th\u00e1ng \u0111\u1ebfn 5 n\u0103m v\u00e0 so s\u00e1nh 110 t\u1ebf b\u00e0o v\u1edbi h\u01a1n 420.000 t\u1ebf b\u00e0o khi k\u1ebft h\u1ee3p v\u1edbi d\u1eef li\u1ec7u tr\u01b0\u1edbc \u0111\u00f3 \u0111\u01b0\u1ee3c thu th\u1eadp tr\u01b0\u1edbc \u0111\u00f3. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ki\u1ec3m tra bi\u1ec3u hi\u1ec7n gen, qu\u00e1 tr\u00ecnh methyl h\u00f3a DNA, h\u00ecnh d\u1ea1ng t\u1ebf b\u00e0o v\u00e0 ho\u1ea1t \u0111\u1ed9ng \u0111i\u1ec7n \u1edf nhi\u1ec1u th\u1eddi \u0111i\u1ec3m.<\/p>\n

Vi\u1ec7c c\u00e1c t\u1ebf b\u00e0o theo d\u00f5i th\u1eddi gian c\u00f3 \u00fd ngh\u0129a g\u00ec?<\/h2>\n

Ch\u00fang t\u00f4i s\u1eed d\u1ee5ng c\u00e1c b\u00f3 gen v\u00e0 d\u1ea5u hi\u1ec7u methyl h\u00f3a DNA thay \u0111\u1ed5i theo \u0111\u1ed9 tu\u1ed5i gi\u1ed1ng nh\u01b0 m\u1ed9t chi\u1ebfc \u0111\u1ed3ng h\u1ed3. Tu\u1ed5i d\u1ef1 \u0111o\u00e1n c\u1ee7a c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 ph\u00f9 h\u1ee3p m\u1ea1nh m\u1ebd v\u1edbi th\u1eddi k\u1ef3 nu\u00f4i c\u1ea5y. \u0110i\u1ec1u n\u00e0y kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 c\u00e1c t\u1ebf b\u00e0o bi\u1ebft ng\u00e0y d\u01b0\u01a1ng l\u1ecbch, m\u00e0 l\u00e0 ch\u01b0\u01a1ng tr\u00ecnh ph\u00e1t tri\u1ec3n di\u1ec5n ra theo th\u1ee9 t\u1ef1 t\u1eeb n\u0103m n\u00e0y sang n\u0103m kh\u00e1c, th\u1eadm ch\u00ed \u1edf b\u00ean ngo\u00e0i c\u01a1 th\u1ec3.<\/p>\n

\"M\u1ed9t
\u0110\u00e2y l\u00e0 h\u00ecnh \u1ea3nh t\u1ea1o b\u1eb1ng AI \u0111\u1ec3 gi\u1ea3i th\u00edch ch\u1ee7 \u0111\u1ec1, kh\u00f4ng ph\u1ea3i \u1ea3nh ch\u1ee5p s\u1ef1 ki\u1ec7n, quan s\u00e1t hay th\u00ed nghi\u1ec7m th\u1ef1c t\u1ebf.<\/figcaption><\/figure>\n

C\u00e1c t\u1ebf b\u00e0o c\u0169 \u0111\u00e3 nh\u1edb nh\u1eefng g\u00ec?<\/h2>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 t\u1ea1o ra m\u1ed9t m\u00f4 h\u00ecnh k\u1ebft h\u1ee3p c\u00e1c t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n \u1edf c\u00e1c \u0111\u1ed9 tu\u1ed5i kh\u00e1c nhau. C\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong th\u1eddi gian d\u00e0i \u0111\u00e3 b\u1ecf qua b\u01b0\u1edbc t\u00e1i t\u1ea1o t\u1ebf b\u00e0o th\u1ea7n kinh ban \u0111\u1ea7u v\u00e0 nhanh ch\u00f3ng t\u1ea1o ra c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n sau n\u00e0y. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u gi\u1ea3i th\u00edch \u0111\u00e2y l\u00e0 tr\u00ed nh\u1edb t\u1ea1m th\u1eddi t\u1eeb m\u1ed9t giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n \u0111\u00e3 qua.<\/p>\n

T\u1ea1i sao n\u00f3 h\u1eefu \u00edch cho vi\u1ec7c nghi\u00ean c\u1ee9u n\u00e3o b\u1ed9?<\/h2>\n

B\u1ed9 n\u00e3o con ng\u01b0\u1eddi ph\u1ea3i m\u1ea5t g\u1ea7n 20 n\u0103m \u0111\u1ec3 tr\u01b0\u1edfng th\u00e0nh, khi\u1ebfn nh\u1eefng thay \u0111\u1ed5i sau sinh kh\u00f3 c\u00f3 th\u1ec3 nh\u00ecn th\u1ea5y \u0111\u01b0\u1ee3c trong c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt ho\u1eb7c n\u1ec1n v\u0103n h\u00f3a ch\u1ec9 k\u00e9o d\u00e0i v\u00e0i th\u00e1ng. C\u00e1c ch\u1ea5t h\u1eefu c\u01a1 t\u1ed3n t\u1ea1i l\u00e2u d\u00e0i c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u00f4ng c\u1ee5 \u0111\u1ec3 ki\u1ec3m tra m\u1ed9t s\u1ed1 qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n sau n\u00e0y, c\u00e1c b\u1ec7nh ph\u00e1t tri\u1ec3n th\u1ea7n kinh v\u00e0 l\u00e3o h\u00f3a t\u1ebf b\u00e0o theo th\u1ee9 t\u1ef1 th\u1eddi gian.<\/p>\n

Nh\u1eefng g\u00ec c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n h\u01a1n n\u1eefa<\/h2>\n

Ngay c\u1ea3 sau 5 n\u0103m, kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o \u0111\u1ec1u gi\u1eef nguy\u00ean t\u1ef7 l\u1ec7 nh\u01b0 trong n\u00e3o th\u1eadt. \u0110\u1eb7c bi\u1ec7t, khi t\u1ef7 l\u1ec7 t\u1ebf b\u00e0o th\u1ea7n kinh gi\u1ea3m, c\u1ea7n c\u00f3 th\u00eam c\u00e1c th\u00ed nghi\u1ec7m \u0111\u1ec3 thay \u0111\u1ed5i m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y. C\u00e1c nghi\u00ean c\u1ee9u ti\u1ebfp theo n\u00ean b\u1ed5 sung c\u00e1c y\u1ebfu t\u1ed1 c\u00f2n thi\u1ebfu, ch\u1eb3ng h\u1ea1n nh\u01b0 m\u1ea1ch m\u00e1u, t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch v\u00e0 \u0111\u1ea7u v\u00e0o c\u1ea3m gi\u00e1c, \u0111\u1ed3ng th\u1eddi xem li\u1ec7u k\u1ebft qu\u1ea3 c\u00f3 \u0111\u01b0\u1ee3c nh\u00e2n r\u1ed9ng tr\u00ean nhi\u1ec1u d\u00f2ng t\u1ebf b\u00e0o g\u1ed1c hay kh\u00f4ng.<\/p>\n

Ngu\u1ed3n g\u1ed1c v\u00e0 ki\u1ec3m ch\u1ee9ng \u0111\u1ed9c l\u1eadp<\/h2>\n

Nature original paper<\/a><\/p>\n

NIH official research release<\/a><\/p>\n

Broad Institute independent institutional summary<\/a><\/p>\n

Nature Portfolio independent editorial summary<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Khi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u nu\u00f4i c\u1ea5y c\u00e1c c\u01a1 quan v\u1ecf n\u00e3o \u0111\u01b0\u1ee3c l\u00e0m t\u1eeb t\u1ebf b\u00e0o g\u1ed1c c\u1ee7a con ng\u01b0\u1eddi trong h\u01a1n 5 n\u0103m, ho\u1ea1t \u0111\u1ed9ng c\u1ee7a gen v\u00e0 c\u00e1c d\u1ea5u hi\u1ec7u DNA \u0111\u00e3 tr\u01b0\u1edfng th\u00e0nh theo th\u1eddi gian nu\u00f4i c\u1ea5y th\u1ef1c t\u1ebf. N\u00f3 kh\u00f4ng ph\u1ea3i l\u00e0 b\u1eb1ng ch\u1ee9ng c\u1ee7a m\u1ed9t b\u1ed9 n\u00e3o hay \u00fd th\u1ee9c ho\u00e0n ch\u1ec9nh.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"class_list":["post-1419","briefing","type-briefing","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing\/1419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/briefing"}],"about":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/types\/briefing"}],"wp:attachment":[{"href":"https:\/\/onepress.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=1419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}